T细胞在支气管哮喘并抑郁发病机制中的作用_West China Medical Journal

Authors：

何敏 , 王婷 ,  姬郁林

Corresponding author：

姬郁林, Email: duoduohm@163.com

Keywords：

哮喘; 抑郁; T淋巴细胞; 病因学

DOI：

CNKI: 51-1356/R.20120214.1341.018

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支气管哮喘与抑郁存在较高的共病率，T细胞对支气管哮喘与抑郁的免疫调节作用及细胞因子与支气管哮喘、抑郁间的病因学关系提示：支气管哮喘与抑郁可能具有部分交叉的病因学机制，哮喘患者合并负性心境状态出现可能与哮喘炎症过程T细胞调节失常及复杂的细胞因子网络有关。对相应T细胞在支气管哮喘伴抑郁发病机制中的作用作一综述，以深入探讨支气管哮喘并抑郁的发病机制。

Citation： 何敏,王婷,姬郁林. T细胞在支气管哮喘并抑郁发病机制中的作用. West China Medical Journal, 2012, 27(2): 294-299. doi: CNKI: 51-1356/R.20120214.1341.018 Copy

1.	The Global Initiative for Asthma. Global strategy for asthma management and prevention[R/IOL]. (2011-03-39)[2011-12-01]. http://www.ginasthma.org/guildline-report-2010.html.
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3.	Scott KM, Von Korff M, Ormel J, et al. Mental disorders among adults with asthma: results from the World Mental Health Survey[J]. Gen Hosp Psychiatry, 2007, 29(2): 123-133.
4.	Goodwin RD, Castro M, Kovacs M. Major depression and allergy: does neuroticism explain the relationship?[J]. Psychosom Med, 2006, 68(1): 94-98.
5.	Van Lieshout RJ, Bienenstock J, MacQueen GM. A review of candidate pathways underlying the association between asthma and major depressive disorder[J]. Psychosom Med, 2009, 71(2): 187-195.
6.	Robinson DS. The role of the T cell in asthma[J]. J Allergy Clin Immunol, 2010, 126(6): 1081-1093.
7.	Chung KF, Barnes PJ. Cytokines in asthma[J]. Thorax, 1999, 54(9): 825-857.
8.	American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders (DSM-IV-TR)[M/OL]. Arlington: American Psychiatric Association 2000. http://www.psych.org.
9.	Irwin MR, Miller AH. Depressive disorders and immunity: 20 years of progress and discovery[J]. Brain Behav Immun, 2007, 21(4): 374-383.
10.	Lavoie KL, Bacon SL, Barone S, et al. What is worse for asthma control and quality of life: depressive disorders, anxiety disorders, or both?[J]. Chest, 2006, 130(4): 1039-1047.
11.	王岚, 莫祖聪, 姬郁林. 负面心境状态与支气管哮喘控制水平及其生活质量的相关性研究[J]. 四川大学学报(医学版), 2009, 40(3): 544-547.
12.	Bender BG. Risk taking, depression, adherence, and symptom control in adolescents and young adults with asthma[J]. Am J Respir Crit Care Med, 2006, 173(9): 953-957.
13.	Wamboldt MZ, Hewitt JK, Schmitz S, et al. Familial association between allergic disorders and depression in adult Finnish twins[J]. Am J Med Genet, 2000, 96(2): 146-153.
14.	Wright RJ, Cohen R, Cohen S. The impact of stress on the development and expression of atopy[J]. Curr Opin Allergy Cl, 2005, 5(1): 23-29.
15.	Humbert M, Durham SR, Ying S, et al. IL-4 and IL-5 mRNA and protein in bronchial biopsies from patients with atopic and nonatopic asthma: evidence against ‘‘intrinsic’’ asthma being a distinct immunopathologic entity[J]. Am J Resp Crit Care, 1996, 154(5): 1497-1504.
16.	Moner R, Mikova O, Koutsilieri E, et al. Consensus paper of the WFSBP task force on biological markers: biological markers in depression[J]. World J Biol Psychia, 2007, 8(3): 141-174.
17.	Zorrilla EP, Luborsky L, McKay JR, et al. The relationship of depression and stressors to immunological assays: a meta-analytic review[J]. Brain Behav Immun, 2001, 15(3): 199-226.
18.	Miller AH. Depression and immunity: a role for T cells?[J]. Brain Behav Immun, 2010, 24(1): 1-8.
19.	Myint AM, Leonard BE, Steinbusch HWM et al. Th1, Th2, and Th3 cytokine alterations in major depression[J]. J Affect Disorders, 2005, 88(2): 167-173.
20.	Kim YK, Na KS, Shin KH, et al. Cytokine imbalance in the pathophysiology of major depressive disorder[J]. Prog Neuropsychopharmacol Biol Psychiatry, 2007, 31(5): 1044-1053.
21.	Hernandez ME, Mendieta D, Martinez-Fong D, et al. Variations in circulating cytokine levels during 52 week course of treatment with SSRI for major depressive disorder[J]. Eur Neuropsychopharm, 2008, 18(12): 917-924.
22.	Musselman DL, Lawson DH, Gumnick JF, et al. Paroxetine for the prevention of depression induced by high-dose interferon alfa[J]. New Engl J Med. 2001, 344(13): 961-966.
23.	Dantzer R, O’Connor JC, Freund GG, et al. From inflammation to sickness and depression: when the immune system subjugates the brain[J]. Nat Rev Neurosci, 2008, 9(1): 46-57.
24.	Howren MB, Lamkin DM, Suls J. Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis[J]. Psychosom Med, 2009, 71(2): 171-186.
25.	Dowlati Y, Herrmann N, Swardfager W, et al. A Meta-analysis of cytokines in major depression[J]. Biological Psychiatry, 2010, 67(5): 446-457.
26.	Kimura A, Kishimoto T. IL-6: regulator of Treg/Th17 balance[J]. Eur J Immunol, 2010, 40(7): 1830-1835.
27.	Kishimoto T. IL-6: from its discovery to clinical applications[J]. Int Immunol, 2010, 22(5): 347-352.
28.	Maes M, Scharpe S, Meltzer HY, et al. Relationships between interleukin-6 activity, acute phase proteins, and function of the hypothalamic-pituitary-adrenal axis in severe depression[J]. Psychiat Res, 1993, 49(1): 11-27.
29.	Levine J, Barak Y, Chengappa KN, et al. Cerebrospinal cytokine levels in patients with acute depression[J]. Neuropsychobiology, 1999, 40(4): 171-176.
30.	Bluthe RM, Michaud B, Poli V, et al. Role of IL-6 in cytokine-induced sickness behavior: a study with IL-6 deficient mice[J]. Physiol Behav, 2000, 70(3-4): 367-373.
31.	Berry MA, Hargadon B, Shelley M, et al. Evidence of a role of tumor necrosis factor alpha in refractory asthma[J]. New Engl J Med, 2006, 354(7): 697-708.
32.	Ying S, Robinson DS, Varney V, et al. TNF alpha mRNA expression in allergic inflammation[J]. Clin Exp Allergy, 1991, 21(6): 745-750.
33.	Thomas PS, Yates DH, Barnes PJ. Tumor necrosis factor-alpha increases airway responsiveness and sputum neutrophilia in normal human subjects[J]. Am J Resp Crit Care, 1995, 152(1): 76-80.
34.	Thomas PS, Heywood G. Effects of inhaled tumour necrosis factor alpha in subjects with mild asthma[J]. Thorax, 2002, 57(9): 774-778.
35.	Desai D, Brightling C. Cytokine and anti-cytokine therapy in asthma: ready for the clinic?[J]. Clin Exp Immunol, 2009, 158(1): 10-19.
36.	Simen BB, Duman CH, Simen AA, et al. TNFalpha signaling in depression and anxiety: behavioral consequences of individual receptor targeting[J]. Biol Psychiat, 2006, 59(9): 775-785.
37.	Bochner BS, Luscinskas FW, Gimbrone MA, et al. Adhesion of human basophils, eosinophils, and neutrophils to interleukin 1-activated human vascular endothelial cells: contributions of endothelial cell adhesion molecules[J]. J Exp Med, 1991, 173(6): 1553-1557.
38.	Barrientos RM, Sprunger DB, Campeau S, et al. Brain-derived neurotrophic factor mRNA downregulation produced by social isolation is blocked by intrahippocampal interleukin-1 receptor antagonist[J]. Neuroscience, 2003, 121(4): 847-853.
39.	Goshen I, Kreisel T, Ben-Menachem-Zidon O, et al. Brain interleukin-1 mediates chronic stress-induced depression in mice via adrenocortical activation and hippocampal neurogenesis suppression[J]. Mol Psychiatr, 2008, 13(7): 717-728.
40.	Pavon L, Sandoval-Lopez G, Hernandez ME, et al. Th2 cytokine response in Major Depressive Disorder patients before treatment[J]. J Neuroimmunol, 2006, 172(1-2): 156-165.
41.	Hartl D, Koller B, Mehlhorn AT, et al. Quantitative and functional impairment of pulmonary CD4+ CD25hi regulatory T cells in pediatric asthma[J]. J Allergy Clin Immun, 2007, 119(5): 1258-1266.
42.	Li Y, Xiao B, Qiu WJ, et al. Altered expression of CD4+ CD25+regulatory T cells and its 5-HT1a receptor in patients with major depression disorder[J]. J Affect Disorders, 2010, 124(1-2): 68-75.
43.	Himmerich H, Milenovic S, Fulda S, et al. Regulatory T cells increased while IL-1beta decreased during antidepressant therapy[J]. J Psychiatr Res, 2010, 44(15): 1052-1057.

1. 　The Global Initiative for Asthma. Global strategy for asthma management and prevention[R/IOL]. (2011-03-39)[2011-12-01]. http://www.ginasthma.org/guildline-report-2010.html.
2. 　Masoli M, Fabian D, Holt S, et al. Global burden of asthma[R/OL]. (2004-05-04)[2011-12-01].Global initiative for Asthma(GINA). http://www.ginasthma.org/pdf/GINABurderReport. pdf.
3. 　Scott KM, Von Korff M, Ormel J, et al. Mental disorders among adults with asthma: results from the World Mental Health Survey[J]. Gen Hosp Psychiatry, 2007, 29(2): 123-133.
4. 　Goodwin RD, Castro M, Kovacs M. Major depression and allergy: does neuroticism explain the relationship?[J]. Psychosom Med, 2006, 68(1): 94-98.
5. 　Van Lieshout RJ, Bienenstock J, MacQueen GM. A review of candidate pathways underlying the association between asthma and major depressive disorder[J]. Psychosom Med, 2009, 71(2): 187-195.
6. 　Robinson DS. The role of the T cell in asthma[J]. J Allergy Clin Immunol, 2010, 126(6): 1081-1093.
7. 　Chung KF, Barnes PJ. Cytokines in asthma[J]. Thorax, 1999, 54(9): 825-857.
8. 　American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders (DSM-IV-TR)[M/OL]. Arlington: American Psychiatric Association 2000. http://www.psych.org.
9. 　Irwin MR, Miller AH. Depressive disorders and immunity: 20 years of progress and discovery[J]. Brain Behav Immun, 2007, 21(4): 374-383.
10. 　Lavoie KL, Bacon SL, Barone S, et al. What is worse for asthma control and quality of life: depressive disorders, anxiety disorders, or both?[J]. Chest, 2006, 130(4): 1039-1047.
11. 　王岚, 莫祖聪, 姬郁林. 负面心境状态与支气管哮喘控制水平及其生活质量的相关性研究[J]. 四川大学学报(医学版), 2009, 40(3): 544-547.
12. 　Bender BG. Risk taking, depression, adherence, and symptom control in adolescents and young adults with asthma[J]. Am J Respir Crit Care Med, 2006, 173(9): 953-957.
13. 　Wamboldt MZ, Hewitt JK, Schmitz S, et al. Familial association between allergic disorders and depression in adult Finnish twins[J]. Am J Med Genet, 2000, 96(2): 146-153.
14. 　Wright RJ, Cohen R, Cohen S. The impact of stress on the development and expression of atopy[J]. Curr Opin Allergy Cl, 2005, 5(1): 23-29.
15. 　Humbert M, Durham SR, Ying S, et al. IL-4 and IL-5 mRNA and protein in bronchial biopsies from patients with atopic and nonatopic asthma: evidence against ‘‘intrinsic’’ asthma being a distinct immunopathologic entity[J]. Am J Resp Crit Care, 1996, 154(5): 1497-1504.
16. 　Moner R, Mikova O, Koutsilieri E, et al. Consensus paper of the WFSBP task force on biological markers: biological markers in depression[J]. World J Biol Psychia, 2007, 8(3): 141-174.
17. 　Zorrilla EP, Luborsky L, McKay JR, et al. The relationship of depression and stressors to immunological assays: a meta-analytic review[J]. Brain Behav Immun, 2001, 15(3): 199-226.
18. 　Miller AH. Depression and immunity: a role for T cells?[J]. Brain Behav Immun, 2010, 24(1): 1-8.
19. 　Myint AM, Leonard BE, Steinbusch HWM et al. Th1, Th2, and Th3 cytokine alterations in major depression[J]. J Affect Disorders, 2005, 88(2): 167-173.
20. 　Kim YK, Na KS, Shin KH, et al. Cytokine imbalance in the pathophysiology of major depressive disorder[J]. Prog Neuropsychopharmacol Biol Psychiatry, 2007, 31(5): 1044-1053.
21. 　Hernandez ME, Mendieta D, Martinez-Fong D, et al. Variations in circulating cytokine levels during 52 week course of treatment with SSRI for major depressive disorder[J]. Eur Neuropsychopharm, 2008, 18(12): 917-924.
22. 　Musselman DL, Lawson DH, Gumnick JF, et al. Paroxetine for the prevention of depression induced by high-dose interferon alfa[J]. New Engl J Med. 2001, 344(13): 961-966.
23. 　Dantzer R, O’Connor JC, Freund GG, et al. From inflammation to sickness and depression: when the immune system subjugates the brain[J]. Nat Rev Neurosci, 2008, 9(1): 46-57.
24. 　Howren MB, Lamkin DM, Suls J. Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis[J]. Psychosom Med, 2009, 71(2): 171-186.
25. 　Dowlati Y, Herrmann N, Swardfager W, et al. A Meta-analysis of cytokines in major depression[J]. Biological Psychiatry, 2010, 67(5): 446-457.
26. 　Kimura A, Kishimoto T. IL-6: regulator of Treg/Th17 balance[J]. Eur J Immunol, 2010, 40(7): 1830-1835.
27. 　Kishimoto T. IL-6: from its discovery to clinical applications[J]. Int Immunol, 2010, 22(5): 347-352.
28. 　Maes M, Scharpe S, Meltzer HY, et al. Relationships between interleukin-6 activity, acute phase proteins, and function of the hypothalamic-pituitary-adrenal axis in severe depression[J]. Psychiat Res, 1993, 49(1): 11-27.
29. 　Levine J, Barak Y, Chengappa KN, et al. Cerebrospinal cytokine levels in patients with acute depression[J]. Neuropsychobiology, 1999, 40(4): 171-176.
30. 　Bluthe RM, Michaud B, Poli V, et al. Role of IL-6 in cytokine-induced sickness behavior: a study with IL-6 deficient mice[J]. Physiol Behav, 2000, 70(3-4): 367-373.
31. 　Berry MA, Hargadon B, Shelley M, et al. Evidence of a role of tumor necrosis factor alpha in refractory asthma[J]. New Engl J Med, 2006, 354(7): 697-708.
32. 　Ying S, Robinson DS, Varney V, et al. TNF alpha mRNA expression in allergic inflammation[J]. Clin Exp Allergy, 1991, 21(6): 745-750.
33. 　Thomas PS, Yates DH, Barnes PJ. Tumor necrosis factor-alpha increases airway responsiveness and sputum neutrophilia in normal human subjects[J]. Am J Resp Crit Care, 1995, 152(1): 76-80.
34. 　Thomas PS, Heywood G. Effects of inhaled tumour necrosis factor alpha in subjects with mild asthma[J]. Thorax, 2002, 57(9): 774-778.
35. 　Desai D, Brightling C. Cytokine and anti-cytokine therapy in asthma: ready for the clinic?[J]. Clin Exp Immunol, 2009, 158(1): 10-19.
36. 　Simen BB, Duman CH, Simen AA, et al. TNFalpha signaling in depression and anxiety: behavioral consequences of individual receptor targeting[J]. Biol Psychiat, 2006, 59(9): 775-785.
37. 　Bochner BS, Luscinskas FW, Gimbrone MA, et al. Adhesion of human basophils, eosinophils, and neutrophils to interleukin 1-activated human vascular endothelial cells: contributions of endothelial cell adhesion molecules[J]. J Exp Med, 1991, 173(6): 1553-1557.
38. 　Barrientos RM, Sprunger DB, Campeau S, et al. Brain-derived neurotrophic factor mRNA downregulation produced by social isolation is blocked by intrahippocampal interleukin-1 receptor antagonist[J]. Neuroscience, 2003, 121(4): 847-853.
39. 　Goshen I, Kreisel T, Ben-Menachem-Zidon O, et al. Brain interleukin-1 mediates chronic stress-induced depression in mice via adrenocortical activation and hippocampal neurogenesis suppression[J]. Mol Psychiatr, 2008, 13(7): 717-728.
40. 　Pavon L, Sandoval-Lopez G, Hernandez ME, et al. Th2 cytokine response in Major Depressive Disorder patients before treatment[J]. J Neuroimmunol, 2006, 172(1-2): 156-165.
41. 　Hartl D, Koller B, Mehlhorn AT, et al. Quantitative and functional impairment of pulmonary CD4+ CD25hi regulatory T cells in pediatric asthma[J]. J Allergy Clin Immun, 2007, 119(5): 1258-1266.
42. 　Li Y, Xiao B, Qiu WJ, et al. Altered expression of CD4+ CD25+regulatory T cells and its 5-HT1a receptor in patients with major depression disorder[J]. J Affect Disorders, 2010, 124(1-2): 68-75.
43. 　Himmerich H, Milenovic S, Fulda S, et al. Regulatory T cells increased while IL-1beta decreased during antidepressant therapy[J]. J Psychiatr Res, 2010, 44(15): 1052-1057.

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T细胞在支气管哮喘并抑郁发病机制中的作用

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